Key features and details | |
Cat. No. | MABL-2511 |
Name | Anti-Notch3 mAbs |
Clone No. | AFD- 7G7-B10-H3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional assay, WB |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for amino acids 807-884 of human notch3. Notch 3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). |
Alternative Name | Notch 3 extracellular truncation; Notch 3 intracellular domain; Neurogenic locus notch homolog protein 3 |
UniProt | Q9UM47 |
Immunogen | The original mouse version of this antibody was raised by immunizing a mouse with human notch 3. |
Application Notes | The original mouse version of this antibody is suitable for western blot. The mouse version of this antibody has also shown anti-proliferate activities in cancer cells in vitro. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
