Anti-p63 mAbs

Cat. No.

MABL-2584

Name

Anti-p63 mAbs

Clone No.

AFD- 60738-10D8

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA, IHC

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human p63. It acts as a sequence specific DNA binding transcriptional activator or repressor. It is   also involved in notch signaling by probably inducing JAG1 and JAG2 and plays   a role in the regulation of epithelial morphogenesis. The p63 molecule has a   high degree of structural homology with p53 and has three similar functional   domains: N-terminal transcription activation region, core DNA binding region,   and C-terminal oligomerization region.

Alternative Name

TP63; CUSP; Tumor protein 63; chronic   ulcerative stomatitis protein; Keratinocyte transcription factor KET;   Transformation-related protein 63; Tumor protein p73-like; p73L; p40; p51;   4A4

UniProt

Q9H3D4

Immunogen

The original antibody was generated by   immunizing 4-6 weeks old female BALB/c mice with recombinant human p63   protein having a histidine tag.

Application Notes

This antibody is highly similar to   commercially available antibody 4A4 in immunohistochemical staining of p63.   This antibody was used for the immunohistochemical staining of prostate   cancer and breast cancer tissues. This binding specificity and affinity of   this antibody was determined using ELISA. The original IgG1 antibody is   reported to bind human p63 with an affinity constant of 2.47 X 10^9 M^(-1).   Purified 60738-10D8 antibody can specifically detect p63 recombinant protein   in western blot. (CN104447994)

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.