Key features and details | |
Cat. No. | MABL-2589 |
Name | Anti-PA anthrax mAbs |
Clone No. | AFD- W5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Bacillus anthracis |
Basic Information | |
Specificity | This antibody recognizes protective antigen (PA) of anthrax toxin. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. |
Alternative Name | protective antigen; PA; Anthrax toxins translocating protein; PA-83; PA83; anthrax toxin |
UniProt | P13423 |
Immunogen | The original scFv version of this antibody was isolated from a phage display library generated from immunized chimpanzees. |
Application Notes | The original scFv version of this antibody was confirmed to strongly bind anthrax protective antigen (PA) via ElISA (Chen et al., 2006; pmid: 16453257). |
Antibody First Published | Chen et al. Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen J Infect Dis. 2006 Mar 1; 193(5): 625–633. PMID:16453257 |
Note on publication | Describes the generation and characterization of anti-PA and anti-LF anthrax antibodies. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
