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Anti-paraoxon (organophosphate) mAbs

简要描述:

This antibody is specific for paraoxon.

产品参数:

Cat. No.:MABL-2606

Species:Engineer

Species Reactivity:Species independent

Type:Recombinate

Application:Catalyzation, crystallization

详细介绍

Key features and   details


Cat. No.

MABL-2606

Name

Anti-paraoxon (organophosphate) mAbs

Clone No.

AFD-A.17 L47K

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Catalyzation, crystallization

Species Reactivity

Species independent

Basic Information


Specificity

This antibody is   specific for paraoxon.

Alternative Name

L-Leu47Lys; A17 L47K; POX

UniProt


Immunogen

The original antibody was generated via phage display from the Griffin.1 library by panning against   reactive phosphonate ester 1.

Application Notes

This antibody is a   covalent trap for Paraoxon and other organophosphate substrates, catalyzing   the hydrolysis reaction through the SN2 mechanism. The catalytic parameters   of this antibody were measured, and its KD was found to be 170 ± 8 μM;   it exhibited a 340-fold reactivity enhancement for paraoxon relative to   wild-type Ig-paraoxonase. Furthermore, its crystal structure in complex with   paraoxon was determined (Mokrushina et al., 2020; PMID: 32859757).

Antibody First   Published

Mokrushina et al. Multiscale computation delivers organophosphorus reactivity and   stereoselectivity to immunoglobulin scavengers Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22841-22848. doi: 10.1073/pnas.2010317117. Epub 2020 Aug 28 PMID:32859757

Note on publication

The original publication   explores the enhancement of immunoglobulin (Ig) catalytic activity against   organophosphorus toxins through quantum mechanics/molecular mechanics (QM/MM) maturation.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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