Key features and details | |
Cat. No. | MABL-2608 |
Name | Anti-Parathyroid hormone-related protein mAbs |
Clone No. | AFD- 2F8-10-3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | therapeutic, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human parathyroid hormone-related protein. |
Alternative Name | PTHLH; PTH-rP; PTHrP; PLP; PTHrP[107-139]; Parathyroid hormone-like protein |
UniProt | P12272 |
Immunogen | The original antibody was generated by immunizing a human antibody-producing transgenic mouse with human PTHrP. |
Application Notes | The original human IgG2 version of this antibody binds parathyroid hormone-related protein with a binding affinity of 0.11 nM. The binding characterization of the human IgG2 version of this antibody towards PTHrP was done using ELISA. Excess PTHrP production causes hypercalcemia, such as tumor-dependent hypercalcemia often caused by PTHrP secreted by tumor cells in large amounts. This human anti-human PTHrP antibody has had a significant suppressive and therapeutic effect on PTHrP- induced hypercalcemia in a malignant hypercalcemia associated with tumor (MAH) model mice (JP2000080100). |
Antibody First Published | Nobuaki et al. JP2000080100 |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
