Anti-PfRH5 mAbs

Cat. No.

MABL-2679

Name

Anti-PfRH5 mAbs

Clone No.

AFD- QA1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block, ELISA

Species Reactivity

Plasmodium falciparum

Basic Information

Specificity

Alternative Name

P. falciparum RH5; Plasmodium falciparum   Reticulocyte-binding Protein Homologue 5

UniProt

B2L3N7

Immunogen

Human adenovirus serotype 5 (AdHu5).

Application Notes

The antibody binds specifically to PfRH5, a   member of the RH family of proteins of the Plasmodium falciparum which   interacts with the surface protein basigin (CD147) of erythrocytes. The   interaction between the two proteins is necessary for the parasitic invasion   of erythrocytes, known to give rise to the pathology of malaria. The antibody   9AD4 inhibits parasitic growth and the interaction of PfRH5 and basigin.

Antibody First   Published

Douglas AD, Williams AR, Knuepfer E,   Illingworth JJ, Furze JM, Crosnier C, Choudhary P, Bustamante LY, Zakutansky  SE, Awuah DK, Alanine DG, Theron M, Worth A, Shimkets R, Rayner JC, Holder   AA, Wright GJ, Draper SJ. Neutralization of Plasmodium falciparum merozoites   by antibodies against PfRH5. J Immunol. 2014 Jan 1;192(1):245-58.   PMID:24293631

Note on publication

Describes the role of the   reticulocyte-binding protein homologue family of proteins found in Plasmodium   falciparum, of which RH5 is necessary for erythrocyte invasion. This is   essential to the life cycle of the parasite, and is responsible for the   development of malaria. Antibodies against PfRH5, such as 9AD4 and QA1,   prevent parasite growth and have the potential to be used therapeutically in   malaria vaccines.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.