Anti-PGE2 mAbs

Cat. No.

MABL-2681

Name

Anti-PGE2 mAbs

Clone No.

AFD- mAbPGE

From

Recombinant Antibody

Isotype

Engineer antibody

Application

RIA, ELISA

Species Reactivity

Species independent

Basic Information

Specificity

Alternative Name

Prostaglandin E2

UniProt

Immunogen

Human PGE2.

Application Notes

The antibody binds specifically to PGE2, a lipid   compound synthesised from the oxidation of arachidonic acid by   cyclooxygenases (COX-1 and COX-2), and from the action of prostaglandin E   synthase on prostaglandin H2. PGE2 is an important inflammatory mediator and   homeostatic factor that acts on the receptors EP1, EP2 and EP3, which are all   members of the family of G-protein coupled receptors (GPCRs). The   neutralisation of PGE2 by the use of monoclonal antibodies provides an   alternative to the use of NSAIDs in the treatment of acute and chronic inflammatory   diseases such as rheumatoid arthritis.

Antibody First   Published

Shono F, Yokota K, Horie K, Yamamoto S,   Yamashita K, Watanabe K, Miyazaki H. A heterologous enzyme immunoassay of   prostaglandin E2 using a stable enzyme-labeled hapten mimic. Anal Biochem.   1988 Feb 1;168(2):284-91. PMID:3129960

Note on publication

Describes the development of an enzyme   immunoassay for PGE2 utilising an anti- PGE2 antibody, in order to measure   the amount of PGE2 present in human urine samples.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.