Anti-Receptor tyrosine-protein kinase erbB-3 mAbs

Cat. No.

MABL-2817

Name

Anti-Receptor tyrosine-protein kinase erbB-3 mAbs

Clone No.

AFD- BCD090-M2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

crystallography, SPR

Species Reactivity

Human

Basic Information

Specificity

BCD090-M2 recognises erbB3, a receptor   tyrosine kinase. The overexpression of erbB3 in breast cancers is associated   with reduced survival in patients.

Alternative Name

HER3; Proto-oncogene-like protein c-ErbB-3;   tyrosine kinase-type cell surface receptor HER3; erbB3

UniProt

P21860

Immunogen

The sdAb was selected from a Llama-derived   phage antibody library.

Application Notes

The crystal structure of BCD090-M2 has been obtained   (Eliseev et al, 2018). SPR indicates the equilibrium dissociation constant   for BCD090-M2 bound to immobilised erbB3 is 1 μm (Eliseev et al, 2018).

Antibody First   Published

Eliseev et al, 2018. Crystal structures of a   llama VHH antibody BCD090-M2 targeting human ErbB3 receptor F1000Research   2018, 7:57

Note on publication

Describes the purification of BCD090-M2 from   the phage antibody library and its characterisation through SPR and   crystallography.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.