Anti-Survivin mAbs

Cat. No.

MABL-2995

Name

Anti-Survivin mAbs

Clone No.

AFD-R7-A

From

Recombinant Antibody

Isotype

Engineer antibody

Application

SPR, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human survivin.

Alternative Name

BIRC5; API4; IAP4;   Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis   inhibitor survivin

UniProt

O15392

Immunogen

The original antibody   was isolated by in vitro selection a VHH using cDNA display with an   artificial synthesized library without animal immunization.

Application Notes

This antibody can be   used to detect human survivin using ELISA. The Kd of R7-A was measured by   ELISA and SPR. The analysis showed that the affinity of R7-A toward survivin   was on the order of 10^-7 to 10^-8 M (PMID: 30119893).

Antibody First   Published

Suzuki et al.   Anti-survivin single-domain antibodies derived from an artificial library   including three synthetic random regions by in vitro selection using cDNA   display. Biochem Biophys Res Commun. 2018 Sep   10;503(3):2054-2060. PMID:30119893

Note on publication

The paper describes an   in vitro selection method for screening VHHs against a target molecule.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.