Anti-TACE mAbs

Cat. No.

MABL-3000

Name

Anti-TACE mAbs

Clone No.

AFD- D1 (A12)

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human (not mouse) TACE   catalytic and non-catalytic domains.

Alternative Name

ADAM17; tumor necrosis factor-α-converting   enzyme; CD156b

UniProt

P78536

Immunogen

Recombinant human ADAM17 (TACE) ectodomain   tagged to biotin.

Application Notes

TACE (CD156b) has proved capable of cleaving   epidermal growth factor receptor (EGFR) ligands, extracellular Notch1,  cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an   indispensable activation event for many of these substrates, TACE has emerged as an attractive therapeutic target for the treatment of cancer and   rheumatoid arthritis. This “cross-domain” human antibody is a selective TACE   antagonist and provides a unique alternative to smallmolecule metalloprotease   inhibition. Note from inventor: "D1(A12) is conformation sensitive and   sees only a specific form of the native enzyme (reflecting its redox state).   It does not work by IHC or WB. It was designed as a potential drug, active in   native situations".

Antibody First   Published

Tape et al. Cross-domain inhibition of TACE   ectodomain Proc Natl Acad Sci U S A. 108(14):5578-83 PMID:21415364

Note on publication

Describes the generation and   characterisation of this antibody by phage-display.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.