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Anti-Tetanus toxoid mAbs

简要描述:

This antibody binds the intact or wild type tetanus toxin of Clostridium tetani. It was also reported to bind the tetanus toxin fragment B. Tetanus toxin is an extremely potent neurotoxin produced by Clostridium tetani.

产品参数:

Cat. No.:MABL-3040

Species:Engineer

Species Reactivity:Clostridium tetani

Type:Recombinate

Application:​functional assay, neutralize, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-3040

Name

Anti-Tetanus toxoid mAbs

Clone No.

AFD- 9F12

From

Recombinant Antibody

Isotype

Engineer antibody

Application

functional assay, neutralize, ELISA

Species Reactivity

Clostridium tetani

Basic Information


Specificity

This antibody binds the intact or wild type tetanus toxin of Clostridium tetani. It was also reported to bind the tetanus   toxin fragment B. Tetanus toxin is an extremely potent neurotoxin produced by   Clostridium tetani.

Alternative Name

TT; TTx; Tetanus toxin; tetX; Tentoxylysin

UniProt

P04958

Immunogen

The original antibody was generated from the peripheral blood mononuclear cells form human donors after immunization with tetanus   toxoids and fusing these lymphocytes with mouse myeloma line P3-X63-Ag 8.653.

Application Notes

The screening of hybridoma supernatants to identify binding towards tetanus toxin was done using ELISA. The protective capacity of this antibody against tetanus toxoid was tested using the mouse   tetanus toxin neutralization assay. The mice which received the tetanus toxin   preincubated with 9F12 were completely protected (PMID: 7174795). The   original antibody was used to study the role of gangliosides in the binding   and internalization of bacterial toxins (PMID: 11093135).

Antibody First   Published

Gigliotti et al. Protective human hybridoma   antibody to tetanus toxin. J Clin Invest. 1982 Dec;70(6):1306-9. PMID:7174795

Note on publication

Describes the generation and neutralization capacity of this antibody towards tetanus toxin.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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