Anti-TGFalpha mAbs

Cat. No.

MABL-3053

Name

Anti-TGFalpha mAbs

Clone No.

AFD- tAb2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

dotblot, ITC, XRC, ELISA

Species Reactivity

Human

Basic Information

Specificity

tAb2 binds the N-terminal sequence of transforming   growth factor alpha, VVSHFND (with residues 4 to 7 being the minimal binding   epitope).

Alternative Name

TGFA, Transforming growth factor A

UniProt

P01135

Immunogen

Biologically active hemocyanin-coupled human   TGFalpha.

Application Notes

Human transforming growth factora (TGFa) consists of 50 amino acid residues with three disulphide bridges. It belongs   to the family of epidermal growth factor related peptides and binds to   EGFreceptor. It is involved in cell proliferation in healthy cells and is found in various cancer cells. Transfection of Fibroblasts with the TGFa gene   induces tumor formation.

Antibody First   Published

Hoeprich PD Jr Identification of   Immunodominant Regions of Transforming Growth Factor alpha J Biol Chem. 1989   Nov 15;264(32):19086-91.2478554

Note on publication

Describes the generation of various anti-TGFalpha antibodies and characterisation of their epitopes and binding affinitites.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.