Key features and details | |
Cat. No. | MABL-3085 |
Name | Anti-TIM-3 mAbs |
Clone No. | AFD-8E 11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein expressed on the cell surface of IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. This protein is also expressed on the surface of Th17 cells, regulatory T-cells and innate immune cells like dendritic cells, NK cells and monocytes. It is a cell surface receptor implicated in modulating innate and adaptive immune responses. |
Alternative Name | CD366; HAVCR2; HAVcr-2; TIM3; TIMD-3; TIMD3; Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3 |
UniProt | Q8TDQ0 |
Immunogen | The original antibody was generated by immunizing 6-8 weeks old female BALB/c mice with recombinant human TIM-3 protein. |
Application Notes | This antibody can be used in the detection of human TIM-3 using ELISA. The binding characterization of this antibody for human TIM-3 was done using indirect immunofluorescence labelling and flow cytometry (CN106632675). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
