Key features and details | |
Cat. No. | MABL-284 |
Name | Anti-11-Deoxycortisol mAbs |
Clone No. | AFD-CET-M8 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, ELISA |
Species Reactivity | n/a |
Basic Information | |
Specificity | Binds specifically to 11-deoxycortisol. No cross-reactivity with cortisol or cortisone |
Alternative Name | Cortodoxone; 17-hydroxy-11-deoxycorticosterone; 17alpha,21- dihydroxyprogesterone; cortexolone |
UniProt | |
Immunogen | 4-(2-carboxyethylthio)-11-deoxycortisol linked to bovine serum albumin. |
Application Notes | The antibody binds specifically to 11-Deoxycortisol, a glucocorticoid steroid hormone which can be oxygenated to cortisol. The monoclonal antibody recognises the functional groups at C-11 and C-21 in the steroid portion of 11-deoxycortisol, and can be useful in determining plasma levels of deoxycortisol in the metyrapone test in the diagnosis of Cushing's syndrome and adrenal insufficiency. |
Antibody First Published | Hosoda et al. Production and Specificity of a Monoclonal Anti-11- deoxycortisol Antibody. CChem Pharm Bull (Tokyo). 1986 Jul;34(7):2914-8. PMID:3769092 |
Note on publication | Describes the generation of a monoclonal antibody against 11-deoxycortisol and studies on its specificity and cross-reactivity. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
