Anti-A2A-Adenosine Receptor mAbs

Cat. No.

MABL-334

Name

Anti-A2A-Adenosine Receptor mAbs

Clone No.

AFD- Ig2838

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody binds specifically to the human A2 adenosine receptor.

Alternative Name

ADORA2A

UniProt

P29274

Immunogen

Human recombinant A2-adenosine receptor.

Application Notes

This antibody binds to the A2 adenosine receptor,  a G-protein-coupled receptor for adenosine that, upon ligand binding,   activates adenylyl cyclase. The antibody acts as an allosteric inhibitor.

Antibody First Published

Hino et al. G-protein coupled receptor   inactivation by an allosteric inverseagonist antibody. Nature 2012; 482(7384):237-240 PMID:22286059

Note on publication

Describes the generation of an   anti-adenosine receptor antibody and crystallization for structure   determination.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.