Key features and details | |
Cat. No. | MABL-344 |
Name | Anti-Acetylated Integrase mAbs |
Clone No. | AFD-VH-112A |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, IP, ELISA |
Species Reactivity | HIV-1 |
Basic Information | |
Specificity | The original antibody is specific for acetylated integrase and it is not able to interact with non-acetylated version of the protein. |
Alternative Name | acetylated HIV-integrase |
UniProt | |
Immunogen | The original antibody was isolated from a mouse naïve ScFv library by panning against acetylated HIV-integrase. |
Application Notes | The specificity of the antibody was confirmed by ELISA analysis. The original format of the antibody co-immunoprecipitated purified Ac-Integrase. The original format of the antibody inhibited the viral infectivity on HeLa cells infected with an HIV virus. The original format of the antibody detected Ac-integrase by western blot analysis (US11137393B2). |
Antibody First Published | Chirichella et al. Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies Nat Methods. 2017 Mar;14(3):279-282. doi: 10.1038/nmeth.4144. Epub 2017 Jan 16. PMID:28092690 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
