Key features and details | |
Cat. No. | MABL-382 |
Name | Anti-Alpha-Fetoprotein mAbs |
Clone No. | AFD- Immu31 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human alpha-fetoprotein. |
Alternative Name | AFP; Alpha-1-fetoprotein; Alpha-fetoglobulin; α-fetoprotein |
UniProt | P02771 |
Immunogen | The original antibody was generated by immunizing a mouse (unspecified) with human alphafetoprotein. |
Application Notes | The specificity of the original version of this antibody (mouse IgG2a) was validated via ELISA. Chimeric and humanized versions of this antibody were subsequently developed and compared (Qu et al., 1999; PMID： 10541349) (US8017736B2). |
Antibody First Published | Qu et al., Humanization of Immu31, an alpha-fetoprotein-specific antibody.Clin Cancer Res. 1999 Oct;5(10 Suppl) 3095s-3100s. PMID：10541349 |
Note on publication | The original publication details the humanization process of Immu31, a murine monoclonal antibody specific to the tumor marker alpha-fetoprotein (AFP), to enhance its suitability for diagnostic and therapeutic applications in humans by preserving its binding affinity while using human antibody frameworks. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
