Key features and details | |
Cat. No. | MABL-486 |
Name | Anti-Basigin mAbs |
Clone No. | AFD- Ab-1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody binds to basigin with an affinity (Kd) of 4 nM reported for the original antibody. |
Alternative Name | CD147; BSG; Cluster of differentiation 147; Extracellular matrix metalloproteinase inducer; EMMPRIN; 5F7; Collagenase stimulatory factor; Leukocyte activation antigen M6; Tumor cell-derived collagenase stimulatory factor; TCSF |
UniProt | P35613 |
Immunogen | Recombinant ectodomains of human basigin. |
Application Notes | The antibody binds specifically to basigin, a protein of the immunoglobulin superfamily which is expressed on the surface of erythrocyte and acts as a receptor for the human malaria parasite P. falciparum. The recombinant chimeric monoclonal antibody Ab-1 acts by blocking the interaction between basigin and PfRH5, a ligand necessary for the P. falciparum erythrocyte invasion, thereby inhibiting the development of malaria. |
Antibody First Published | Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ. Basigin is a druggable target for host-oriented antimalarial interventions. J Exp Med. 2015 Jul 27;212(8)：1145-51. PMID：26195724 |
Note on publication | Describes the development of the recombinant chimeric antibody Ab-1 directed against basigin, an erythrocyte receptor involved in parasite invasion. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
