Anti-C3 mAbs

Cat. No.

MABL-567

Name

Anti-C3 mAbs

Clone No.

AFD-C3-2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

inhibition, SPR, WB, ELISA

Species Reactivity

Human

Basic Information

Specificity

The antibody interacts specifically with native C3, containing an intact thioester bond and not with an inactive form   of C3, containing a hydrolysed ester bond. The epitope in part located on the   23kD-α- chain fragment of C3c.

Alternative Name

Anti-C3-2 mAb; third component of   complement; Complement C3; C3 and PZP-like alpha-2-macroglobulin   domain-containing protein 1

UniProt

P01024

Immunogen

The original antibody was generated   by immunizing mice with purified human C3.

Application Notes

The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the   humanised version of the antibody to native C3 was measured by surface plasmon resonance (Kd= 5.9 nM). The murine and the humanised version of the   antibody could inhibit the activation of C3 (WO2004031240A1).

Antibody First Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.