Key features and details | |
Cat. No. | MABL-610 |
Name | Anti-Capsular antigen mAbs |
Clone No. | AFD- P2I67 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Burkholderia mallei, Burkholderia pseudomallei |
Basic Information | |
Specificity | This antibody binds surface capsular antigens of Burkholderia pseudomallei (BP), a causative agent of melioidosis, is a gram-negative, facultative anaerobic, motile bacillus commonly found in the soil and stagnant waters. BP infection is often due to either direct inoculation into wounds and skin abrasions or inhalation of contaminated materials. Recently, BP has been recognized as a major cause of community- acquired septicemia, resulting in significant mortality. This antibody also cross reacts with surface capsular antigens of Burkholderia mallei. B. mallei (BM), a host-adapted pathogen that does not normally persist in nature, causes glanders in horse. Some studies indicated that BM is highly infectious in humans by aerosol route. |
Alternative Name | surface capsule antigen; Burkholderia mallei; BM; glanders; Burkholderia pseudomallei; BP; Burkholderia spp; melioidosis; Whitmore’s disease |
UniProt | |
Immunogen | The original antibody was generated by immunizing mice with various antigen preparations of B. pseudomallei (ATCC 23343). Later on phage display technique was used to generate scFv version of this antibody. |
Application Notes | This antibody can be used for the detection of capsular antigens of Burkholderia pseudomallei and Burkholderia mallei in a sample using ELISA (PMID: 21172353). |
Antibody First Published | Kim et al. Construction and molecular characterization of mouse single- chain variable fragment antibodies against Burkholderia mallei and Burkholderia pseudomallei. J Immunol Methods. 2011 Feb 28;365(1-2):101-9. PMID:21172353 |
Note on publication | Describes the molecular charcterization of scFv antibodies against Burkholderia mallei and Burkholderia pseudomallei generated using scFv phage display technology. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
