Key features and details | |
Cat. No. | MABL-665 |
Name | Anti-CD10 mAbs |
Clone No. | AFD- SS2/36 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognises neprilysin which is a cell surface enzyme degrading various peptides, such as enkephalins, angiotensins and atrial natriuretic factor. |
Alternative Name | Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; EC 3.4.24; EC 3.4.24.11 |
UniProt | P08473 |
Immunogen | This antibody was raised by immunising mice with common acute lymphoblastic leukaemia cells. |
Application Notes | Anti-Neprilysin antibodies have been used in the characterisation and identification of certain cancers and other conditions. For instance, CD10 (Neprilysin) is an important cell surface marker of human acute lymphocytic leukemia (ALL) and Daskalopoulou and colleagues (2001) used this antibody (along with others) during cytological diagnosis and subclassification of malignant lymphomas as a marker of ALL. SS2/36 antibody was also used for flow cytometric phenotyping of hairy cell leukemia cases (Jasionowski et al., 2003). |
Antibody First Published | Majdic et al. Comparative evaluation of CD10 antibodies. In McMichael AJ, et al (eds) Leucocyte Typing III, Oxford University Press, Oxford, New York and Tokyo, p 488-9. |
Note on publication | This report describes the characterisation of SS2/36 antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
