Name
HBV core (1-186)
Cat. No.
MAG-4426
Tag/Conjugates
His
Source
/
Shipped
Shipped with Ice Packs
Description
HBV core (1-186)
Introduction
Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA(pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
Physical Appearance
His
Formulation
/
Stability
Shipped with Ice Packs
Purity
HBV Core protein is >90% pure as determined by 10% PAGE (Coomassie staining).
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Applications
/
Immunological functions
/
Purification Method
HBV Core protein was purified by proprietary chromatographic technique.
Specificity
Immunoreactive with sera HBV-infected individuals.
