Cat. No.
MABL-6199
Type
Polyclonal Rabbit Antibody.
Shipped
At Room Temperature
Isotype
/
Description
Pancreas Duodenum Homeobox-1, Polyclonal Rabbit Antibody
Introduction
PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.
Formulation
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Immunogen
Recombinant PDX1 E.Coli derived.
Applications
Western Blot: 1:1,000 Immunohistochemistry: 1:500 Optimal working dilutions must be determined by end user. Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1
Stability
Stable for 2 yeas at -20°C. Avoid freeze/thaw cycles.
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Purification Method
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Purity
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Source
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Solubility
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Host
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Physical Appearance
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Storage Procedures
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Specificity
Human and Mouse PDX-1.
Synonyms
IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1.
