Key features and details | |
Cat. No. | MABL-3349 |
Name | Anti-IgE mAbs |
Clone No. | AFD-huMaE11 (Omalizumab) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallization, Block, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to circulating human IgE antibody, but not to cell-bound IgE. It binds in proximity of the binding site of the high-affinity IgE receptor Fc epsilon RI. |
Alternative Name | epsilon chain; Ig epsilon chain C region; immunoglobulin E |
UniProt | P01854 |
Immunogen | Human IgE protein. |
Application Notes | This antibody is the humanized version of original mouse antibody MAE11. This antibody binds to circulating IgE, thereby inhibiting IgE binding to mast-cells. It does not bind to cell-bound IgE and does not provoke histamine release from mast-cells sensitised by IgE. As a human IgG1, marketed as Xolair™, it is used therapeutically to treat asthma and allergies. |
Antibody First Published | Presta et al. Humanization of an antibody directed against IgE. J Immunol. 1993 Sep 1;151(5):2623-32. PMID:8360482 |
Note on publication | Describes the role of the house dust mite allergen Der p 7 in allergy, and the generation of monoclonal antibodies that target Der p 7. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
