Name
Sincalide
Cat. No.
MAG-2746
Tag/Conjugates
His
Source
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Shipped
At Room Temperature
Description
Sincalide also called CCK-8 has a molecular formula of C 49 H 62 N 10 O 16 S 3 , H-Asp-Tyr(SO 3 H)-Met-Gly-Trp-Met-Asp-Phe-NH 2 having an Mw of 1143.29 Dalton.
Introduction
Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystokinin (CCK) is a hormone originally isolated from porcine intestinal mucosa and described as a linear 33-amino acid peptide containing a sulfated tyrosine, which is essential for its biological activity. It has been found in mammals in both the digestive tract and the central nervous system. Among its multiple biological functions, this hormone stimulates pancreatic exocrine secretion, gallbladder contraction, and intestine motility and may also act as a neurotransmitter/neuromodulator in the central nervous system.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
The Sincalide was lyophilized from a concentrated (1mg/ml) solution with no additives.
Solubility
It is recommended to reconstitute the lyophilized Sincalide in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml, which can then be further diluted to other aqueous solutions.
Stability
Lyophilized Sincalide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCK-8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity
Greater than 99.0% as determined by RP-HPLC.
Amino acid sequence
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Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
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Contaminants
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Specific Activity
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