Name
KLK3 Human, Native
Cat. No.
MAG-3311
Tag/Conjugates
His
Source
Human seminal fluid.
Shipped
Shipped with Ice Packs
Description
Human Kallikrein-3 produced in Human seminal fluid having a molecular mass of approximately 30kD.
Introduction
Kallikrein-3 (KLK3) is a part of the kallikrein-related peptidase family. Kallikreins are a subgroup of serine proteases having various physiological functions. Numerous kallikreins take part in carcinogenesis and some may be prospective cancer and other disease biomarkers. Kallikrein-3 is 1 of the 15 kallikrein subfamily members located in a cluster on chromosome 19 and is a protease present in seminal plasma. KLK3 hydrolyzes semenogelin-1 consequently leading to the liquefaction of the seminal coagulum. KLK3 acts normally in the liquefaction of seminal coagulum, probably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of the KLK3 protein, called PSA in the clinical setting, is beneficial in the diagnosis and monitoring of prostatic carcinoma.
Purification Method
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Physical Appearance
Sterile Filtered clear solution.
Formulation
The protein solution (0.2 µm filtered) is in 0.09% NaN3, 0.05M phosphate buffer, 150mM NaCl, pH 7.5.
Stability
Human Kallikrein-3 should be stored at 2-8 ° C. Do not freeze!
Purity
Greater than 96.0%.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS, hK3, KLK2A1
Amino acid sequence
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Background
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