Name
PON1 Human (68-124)
Cat. No.
MAG-3499
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
At Room Temperature
Description
The PON1 Human is created as a recombinant protein with a 4kda N-terminal fusion of His Tag. The PON1 His-Tagged Fusion Protein, produced in E. coli, is a 12kDa protein containing 57 amino acid residues of the PON1 Human, 68-124 amino acids.
Introduction
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Purification Method
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Physical Appearance
Filtered White lyophilized (freeze-dried) powder.
Formulation
Each mg was lyophilized with 1xPBS, 0.4% SDS and 4mM DTT.
Stability
Store lyophilized PON1 at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity
Greater than 90% as determined by SDS-PAGE.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
Serum paraoxonase, arylesterase 1, EC 3.1.1.2, EC 3.1.8.1, PON 1.
Amino acid sequence
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Background
Paraoxonase 1 also known as PON1takes part in the detoxification of organophosphate insecticides such as parathion. PON1 is related to high-density lipoprotein (HDL) in the plasma and takes an important part in lipid metabolism and antioxidant defense. PON1 was first known for its ability to hydrolyze organophosphates and protect against oxidative stress. PON1 reduces oxidative stress by preventing the oxidation of lipids in LDL particles, which is extremely important in mitigating atherosclerosis and other cardiovascular diseases. PON1 has an anti-inflammatory effects which help reduce inflammatory markers in different disease states. PON1 takes part in cholesterol metabolism, influencing the stability and formation of HDL particles, which are vital for lipid transport and reverse cholesterol efflux.
