Name
NAPSA Human
Cat. No.
MAG-3537
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
Shipped with Ice Packs
Description
NAPSA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (64-420 a.a) and having a molecular mass of 40.9kDa.
Introduction
Napsin A Aspartic Peptidase, also known as NAPSA is a member of the
peptidase A1 family. NAPSA is involved in the processing of pneumocyte
surfactant precursors. Furthermore the activation peptides of aspartic proteinases
take part as inhibitors of the active site. These peptide segments/pro-parts are
considered essential for correct folding, targeting, as well as control of the
activation of aspartic proteinase zymogens. The pronapsin A gene is expressed mostly
in lung and kidney. In addition, NAPSA translation product is expected to be a
fully functional, glycosylated aspartic proteinase precursor which contains an
RGD motif as well as an additional 18 residues at its C-terminus.
Purification Method
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Physical Appearance
Sterile filtered colorless solution.
Formulation
NAPSA protein solution (0.25mg/ml) containing 20mM
Tris-HCl (pH8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
Napsin A Aspartic Peptidase, NAP1, NAPA, Kidney-Derived
Aspartic Protease-Like Protein, Aspartyl Protease 4, TA01/TA02, Napsin-1, SNAPA,
Asp 4, ASP4, CTB-191K22.6,
EC 3.4.23.15, Pronapsin A, EC 3.4.23.5, EC 3.4.23.3, EC
3.4.23.-, EC 3.4.23, Napsin-A, KDAP, KAP, Napsin-A.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGS KPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS NLWVPSRRCH
FFSVPCWLHH RFDPKASSSF QANGTKFAIQ YGTGRVDGIL SEDKLTIGGI KGASVIFGEA LWEPSLVFAF
AHFDGILGLG FPILSVEGVR PPMDVLVEQG LLDKPVFSFY
LNRDPEEPDG GELVLGGSDP AHYIPPLTFV PVTVPAYWQI HMERVKVGPG
LTLCAKGCAA ILDTGTSLIT GPTEEIRALH AAIGGIPLLA GEYIILCSEI PKLPAVSFLL GGVWFNLTAH
DYVIQTTRNG VRLCLSGFQA LDVPPPAGPF WILGDVFLGT YVAVFDRGDM KSSARVGLAR
ARTRGADLGW GETAQAQFPG.
Background
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