Name
PPP2R1A Human
Cat. No.
MAG-3630
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
Shipped with Ice Packs
Description
PPP2R1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 612 amino acids (1-589 a.a) and having a molecular mass of 67.7kDa.
Introduction
Protein Phosphatase 2, Regulatory Subunit A
Alpha, also known as PPP2R1A is part of the PPP family of phosphatases,
which regulates a diversity of vital cellular processes. PPP2R1A subunit, PR65,
functions as a scaffolding molecule which coordinates the assembly of the
catalytic subunit and a variable regulatory B subunit. PPP2R1A is essential for
proper chromosome segregation as well as for centromeric localization of SGOL1
in mitosis. Furthermore, PPP2R1A phosphorylation is an in vivo mechanism which
regulates the PP2A signaling complex as well as increasing the PP2A activity in
heart failure.
Purification Method
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Physical Appearance
Sterile filtered colorless solution.
Formulation
PPP2R1A protein solution (1mg/ml) containing Phosphate
Buffered Saline (pH7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Synonyms
PPP2R1A,
Protein Phosphatase 2, Regulatory Subunit A, Alpha, Protein Phosphatase 2
(Formerly 2A), Regulatory Subunit A (PR 65), Alpha Isoform, PP2A Subunit A
Isoform PR65-Alpha, PP2A Subunit A Isoform R1-Alpha, Serine/Threonine Protein
Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Serine/Threonine-Protein
Phosphatase 2A, 65 KDa Regulatory Subunit A Alpha Isoform, Protein Phosphatase
2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform, Medium Tumor
Antigen-Associated 61 KDA Protein, Medium Tumor Antigen-Associated 61 KDa
Protein, 65kDa Regulatory Subunit A, Protein Phosphatase 2A, Protein
Phosphatase 2, Regulatory Subunit A, Alpha Isoform, PP2A-Aalpha, PP2AAALPHA, PR65A.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGS MAAADGD DSLYPIAVLI DELRNEDVQL RLNSIKKLST IALALGVERT RSELLPFLTD TIYDEDEVLL ALAEQLGTFT TLVGGPEYVH CLLPPLESLA TVEETVVRDK AVESLRAISH EHSPSDLEAH FVPLVKRLAG GDWFTSRTSA CGLFSVCYPR VSSAVKAELR QYFRNLCSDD TPMVRRAAAS KLGEFAKVLE LDNVKSEIIP MFSNLASDEQ DSVRLLAVEA CVNIAQLLPQ EDLEALVMPT LRQAAEDKSW RVRYMVADKF TELQKAVGPE ITKTDLVPAF QNLMKDCEAE VRAAASHKVK EFCENLSADC RENVIMSQIL PCIKELVSDA NQHVKSALAS VIMGLSPILG KDNTIEHLLP LFLAQLKDEC PEVRLNIISN LDCVNEVIGI RQLSQSLLPA IVELAEDAKW RVRLAIIEYM PLLAGQLGVE FFDEKLNSLC MAWLVDHVYA IREAATSNLK KLVEKFGKEW AHATIIPKVL AMSGDPNYLH RMTTLFCINV LSEVCGQDIT TKHMLPTVLR MAGDPVANVR FNVAKSLQKI GPILDNSTLQ SEVKPILEKL TQDQDVDVKY FAQEALTVLS LA.
Background
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