Cat. No.
MABL-3780
Application
Immunoscintigraphy
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
BW431/26
From
Recombinant Antibody
Specificity
This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections.
Alternative Names
Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; CEACAM5; Meconium antigen 100; CD66e
UniProt
P06731
Immunogen
The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.
Application Notes
Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5% of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576).
Antibody First Published
Note on publication
Size
261 μg Purified antibody.
Concentration
162 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 461.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 181⁰C.
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