Cat. No.
MABL-010
Application
WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
31C6
From
Recombinant Antibody
Specificity
Binds human PrP residues 143-149.
Alternative Names
PrP; ASCR; CD-Antigen
UniProt
P04156
Immunogen
Recombinant mouse scrapie-Prion protein residues 23-231 (rMoPrP23-231).
Application Notes
This is antibody recognises and binds to residues 143-149 of PrP. High Levels of PrP (Prion Protein) are found in the brain of humans and animals that are infected with transmissible spongiform encephalopathies such as Creutzfeld-Jakob disease (CJD), Gerstmann-Straussler disease in humans or bovine spongiform encephalopathy (BSE) in cattle.
Antibody First Published
Kim et al. 2004 Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies. Virology. 2004; 320(1):40-51 PMID:15003861
Note on publication
Describes the generation of several monoclonal antibodies against PrP by immunising PrP gene-ablated mice with the pathogenic form of PrP
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
