Cat. No.
MABL-012
Application
WB, Block, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
NAC32
From
Recombinant Antibody
Specificity
Binds the nonamyloid component of alpha-Synuclein.
Alternative Names
SNCA
UniProt
P37840
Immunogen
Biotin-labeled peptide spanning amino acids 53-87 of alpha-synuclein.
Application Notes
This is a synthetic IgG binding to alpha-Synuclein which is involved in the regulation of dopamine release and transport. It induces fibrillisation of the tau-protein and reduces the neuronal responsiveness to several apoptotic signals. Involved in the pathogenesis of Parkinson disease.
Antibody First Published
Lynch et al. 2008 An scFv Intrabody against the Nonamyloid component of alpha-Synuclein Reduces Intracellular Aggregation and Toxicity Journal of Molecular Biology 2008; 377:136- 147 PMID:18237741
Note on publication
Describes the generation of an scFv intrabody against the non-amyloid component of alpha-Synulcein and demonstrates its effect in counteracting mutant synuclein aggregation.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
