Cat. No.
MABL-017
Application
NTRL, ELISA
Isotype
Engineer antibody
Species Reactivity
Androctonus australis hector
Clone No.
4C1
From
Recombinant Antibody
Specificity
This scFv binds specifically to the C-terminal region of the toxin.
Alternative Names
neurotoxin II; alpha-mammal toxin II
UniProt
P01484
Immunogen
C-terminus of AahII
Application Notes
This scFv binds to the C-terminus of the neurotoxin AahII, which binds and blocks sodium channels in a voltage-independent manner. The antibody neutralizes the toxin.
Antibody First Published
Mousli et al. 1999 A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector. FEBS Letters 1999; 442(2- 3):183-188 PMID:9928998
Note on publication
Describes the engineering of an scFv that, similar to the whole antibody, neutralizes the activity of the neurotoxin.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
