Cat. No.
MABL-266
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Species independent
Clone No.
AI-K11B
From
Recombinant Antibody
Specificity
This antibody specifically binds anti-morphine antibody 3K11. It is an idiotypic antibody which exhibits the antigenic properties of morphine, binds to opioid receptors. When used for immunization, it induces the production of antibodies that specifically recognize morphine derivatives like 6-hemisuccinyl (GSM), 3-O-carboxymethyl (KMM) and 2-p-carboxy-phenylazomethyl (FAM) esters.
Alternative Names
3K11; anti-idiotypic monoclonal antibody 3K11; opioid receptor
UniProt
Immunogen
The original antibody was generated by immunizing mouse with anti-morphine antibody 3K11 conjugated with KLH.
Application Notes
This antibody is capable of binding to opioid receptors on T98G human glioblastoma cells. This antibody could also recognize conjugate of mAb 3K11 - horseradish peroxidase with 6- hemisuccinyl morphine ester-BSA in an ELISA. The binding affinity of this idiotype antibody to 3K11 was determined to be Kd = 3.2 nM. When rabbits were immunized with AI-K11B antibody, they generated antibodies that were capable of recognizing all tested derivatives of morphine (RU2745374).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
