Key features and details | |
Cat. No. | MABL-027 |
Name | Anti-Prion mAbs |
Clone No. | AFD-3F4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, ELISA, IHC |
Species Reactivity | Hamster, Human |
Basic Information | |
Specificity | / |
Alternative Name | Major prion protein; p27-30; CD30 antigen; prion protein PrP; prion- related protein |
UniProt | |
Immunogen | Hamster 263K PrPs. |
Application Notes | The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form. This plays an essential role in the pathogenesis of certain neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Staussler syndrome (GSS) and bovine spongiform encephalopathy (BSE). These disorders are characterised by an accumulation of prion proteins in the brain, which have a disrupted secondary structure. |
Antibody First Published | Kascsak RJ, Rubenstein R, Merz PA, Tonna-DeMasi M, Fersko R, Carp RI, Wisniewski HM, Diringer H. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol. 1987 Dec;61(12):3688-93. PMID:2446004 |
Note on publication | Describes the generation a species-specific monoclonal antibody directed against protease-resistant proteins (PrPs) in order to study the relationship of PrPs to their host precursor protein and to scrapie-associated fibril proteins. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
