Key features and details | |
Cat. No. | MABL-028 |
Name | Anti-Myelin oligodendrocyte glycoprotein mAbs |
Clone No. | AFD-M45 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, IHC |
Species Reactivity | |
Basic Information | |
Specificity | / |
Alternative Name | MOG |
UniProt | |
Immunogen | Rat MOG. |
Application Notes | The antibody binds specifically to MOG, a transmembrane glycoprotein expressed on the surface of oligodendrocytes in the central nervous system, that plays an important role in maintaining the structure of the myelin sheath. Monoclonal antibodies that target MOG are involved in the pathogenesis of the demyelinating disorder multiple sclerosis (MS). Animals injected with anti-MOG antibodies have been shown to display symptoms of human MS, and can thereby be used as models to study the development of the disease. The monoclonal antibodies M45 and M3-24 bind to distinct epitopes on MOG. |
Antibody First Published | von Büdingen HC, Hauser SL, Nabavi CB, Genain CP. Restrictive and diversifying elements of the anti-myelin/oligodendrocyte glycoprotein antibody response in primate experimental allergic encephalomyelitis. Immunogenetics. April 2006, Volume 58, Issue 2, pp 122-128 PMID:16528499 |
Note on publication | Describes the characterization of the expression of six monoclonal antibodies directed against MOG, in order to study the role of pathogenic autoantibodies in autoimmune diseases such as multiple sclerosis. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
