Key features and details | |
Cat. No. | MABL-060 |
Name | Anti-haloperidol mAbs |
Clone No. | AFD-Clone D |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA |
Species Reactivity | n/a |
Basic Information | |
Specificity | Thi antibody recognises haloperidol which is one of the major antipsychotic drugs. It is a D2 dopamine receptor antagonist and is widely used in treatment of schizophrenia, psychoses and mania. This antibody binds to the p-chlorophenyl ring (ring 2) of haloperidol and prefers an extended conformer of the drug molecule. |
Alternative Name | Haldol; 258(2)-1; D; Einalon S; Eukystol; Aloperidin; Bioperidolo; Brotopon; Dozic; Duraperidol; Halosten; Keselan; Linton; Peluces; Serenace; Sigaperidol |
UniProt | |
Immunogen | This antibody was raised by immunising mice with a haloperidol coupled to BSA via an aminooxyacetic acid arm through the keto group of the butyrophenone chain (oxime conjugate). |
Application Notes | RIA: radioligand binding assays were performed to asses binding affinity of the anti- haloperidol D antibody (Kd=4.4 nM). This antibody possesses a binding site which is highly sensitive to the electron-withdrawing characteristics of the substituents on ring 2 (Sherman et al., 1986). |
Antibody First Published | Bolger et al. Preparation and characterization of antisera and monoclonal antibodies to haloperidol. Immunol Invest. 1985 Dec;14(6):523-40. PMID:2420719 |
Note on publication | This article describes the preparation of the monoclonal antibodies which specifically bind haloperidol, among them this 258(2)-i antibody (later renamed as anti-haloperidol antibody D). |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
