Anti-GABA(A)R, Beta1 mAbs

Cat. No.

MABL-164

Name

Anti-GABA(A)R, Beta1 mAbs

Clone No.

AFD-N96/55.3

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB

Species Reactivity

Rat, Human, Mouse

Basic Information

Specificity

This antibody is specific for amino acids   327-450 of mouse GABA-A-R-Beta1. It shows no cross- reactivity against   GABA-A-R-Beta2 or -Beta3. GABA-A-R-Beta1 is a component of the   heteropentameric receptor for GABA, the major inhibitory neurotransmitter in   the vertebrate brain. It also functions as histamine receptor and mediates   cellular responses to histamine.

Alternative Name

N96/55.3R; Gamma-aminobutyric acid receptor   subunit beta-1; Gabrb1; GABA(A) receptor subunit beta-1

UniProt

P50571

Immunogen

This antibody was raised by immunising   BALB/c mice with a fusion protein of amino acids 327-450 of mouse   GABA-A-R-Beta1.

Application Notes

This antibody has been used for   immunoblotting on rat and mouse brain samples (King et al, 2014;   PMID:24477962). This antibody has been used for immunoblotting on the cortex   of mice (Zhou et al, 2013; PMID:23744069).

Antibody First Published

Zhou et al. Altered cortical GABAA   receptor composition, physiology, and endocytosis in a mouse model of a human   genetic absence epilepsy syndrome J Biol Chem. 2013 Jul 19;288(29):21458-72   PMID:23744069

Note on publication

The effects of Hetα1KO on the expression and   physiology of GABAARs in the mouse cortex was determined.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.