Anti-Kv4.2 potassium channel mAbs

Cat. No.

MABL-186

Name

Anti-Kv4.2 potassium channel mAbs

Clone No.

AFD-L28/4R

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, IF

Species Reactivity

Rat, Human, Mouse

Basic Information

Specificity

This antibody is specific for the Kv4.2 potassium   channel antigen. This protein is a voltage- gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily   in the brain, but also in rodent heart. It mediates the major part of the   dendritic A-type current I(SA) in brain neurons.

Alternative Name

Potassium voltage-gated channel subfamily D member 2; Kcnd2; RK5; Shal1; Voltage-gated potassium channel subunit Kv4.2; L28/4

UniProt

Q63881

Immunogen

This antibody was raised by immunizing a mouse with fusion protein amino acids 471-630 (cytoplasmic C-terminus) of rat Kv4.2.

Application Notes

Immunofluorescence was preformed on Cells   expressing DPPX-S, Kv4.2, and/or KChIPs with this antibody (Seikel and   Trimmer, 2009; PMID:19441798). Cardiac myocytes from mice were immunostained   with this antibody (Kilfoil et al, 2019; PMID:31639389). Mouse left   ventricular tissue lysates were immunoblotted with this antibody (Kilfoil et   al, 2019; PMID:31639389).

Antibody First Published

Seikel and Trimmer Convergent   modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and   KChIP auxiliary subunits Biochemistry. 2009 Jun 23;48(24):5721-30 PMID:19441798

Note on publication

The convergent roles that  DPPX-S and KChIPs play as component subunits of Kv4.2 channel complexes were characterized.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.