Key features and details | |
Cat. No. | MABL-226 |
Name | Anti-CD127 mAbs |
Clone No. | AFD-1A11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | antagonist, SPR, WB, ELISA, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for CD127 epitope regions 2, 3, 4 and 5. |
Alternative Name | IL7R; IL7Rα; IL-7Rα; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R-alpha; IL-7RA; CDw127 |
UniProt | P16871 |
Immunogen | The original antibody was generated by immunizing Balb/c mice with the full ECD of CD127. |
Application Notes | ELISA was performed on CD127 using this antibody (WO2010017468). This antibody was tested for inhibition of IL-7 induced IFN-γ and IL-17 in a TH17 expansion assay (WO2010017468). Surface plasmon resonance was used to assess the ability of this antibody to bind Fc effector receptors (Fc Gamma I, IIa and IIIa) (US9150653). Surface plasmon resonance was performed with this antibody on CD127 to test the binding affinity (WO2010017468). Immunohistochemistry was performed on the spinal cord of a mouse using this antibody (WO2010017468). Western blot was performed on protein extract using this antibody (WO2010017468). |
Antibody First Published | Leung et al. Treatment of autoimmune and inflammatory disease. WO2010017468 |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
