Key features and details | |
Cat. No. | MABL-241 |
Name | Anti-Myelin basic protein mAbs |
Clone No. | AFD-F23C6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis. |
Alternative Name | MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein; F23 |
UniProt | P02686 |
Immunogen | The original antibody was generated by hyperimmunization of BALB/c mice with a synthetic peptide comprising human MBP acetyl residues 1-9. |
Application Notes | This antibody can be used for the detection of human MBP in a sample using ELISA. This antibody was found to react with human MBP peptides like acetyl 1-9, 1-14, and 1-44 (PMID: 1698857). |
Antibody First Published | Zhou et al. An idiotype shared by monoclonal antibodies to different peptides of human myelin basic protein. J Immunol. 1990 Oct 15;145(8):2554-60. PMID:1698857 |
Note on publication | Describes the generation of antibody against human myelin basic protein and describes use of complementary peptide to human MBP peptide 1-9 to raise murine mAb with anti-Id activity. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
