Key features and details | |
Cat. No. | MABL-240 |
Name | Anti-Myelin basic protein mAbs |
Clone No. | AFD-F28C4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis. |
Alternative Name | MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein |
UniProt | P02686 |
Immunogen | The original antibody was generated by immunizing PL/J mice with MBP acetyl residues 1-9. |
Application Notes | This antibody shares a cross reactive idiotpe with the TCRs, possibly as a result of having similar fine epitope specificity and sequence homology (PMID: 7517973). This antibody can be used for the detection of MBP in a solution using ELISA (PMID: 8567971). |
Antibody First Published | Maier et al. A V lambda x-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cellreceptors. J Immunol. 1994 Aug 1;153(3):1132-40. PMID:7517973 |
Note on publication | Describes the generation of this antibody and compares its sequences homology to encephalitogenic T cell receptors. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
