Key features and details | |
Cat. No. | MABL-690 |
Name | Anti-CD11b mAbs |
Clone No. | AFD- VHHCD11b |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, IF |
Species Reactivity | Mouse |
Basic Information | |
Specificity | The antibody is specific for CD11b. |
Alternative Name | CR3A; ITGAM; DC13; VHHDC13; Integrin alpha-M; CR-3 alpha chain; CD11 antigen-like family member B; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor |
UniProt | P05555 |
Immunogen | The original antibody was originated by immunizing a camel with recombinant DC11b. |
Application Notes | The original format of the antibody specifically bound to CD11b+ cells in lymph nodes and spleen by two-photon microscopy and flow cytometry analysis. 18F-labelled antibody was used for noninvasive imaging of CD11b+ cells, both in normal and in tumor-bearing mice (Rashidian et al., 2015; PMID: 25902531). The antibody was conjugated to an H-2Db -restricted immunodominant E7 epitope (an HPV tumor antigen peptide) for treatment of HPV induced cancer (Woodham et al., 2018; PMID: 29792298). |
Antibody First Published | Rashidian et al. Noninvasive imaging of immune responses Proc Natl Acad Sci U S A. 2015 May 12;112(19):6146-51. doi: 10.1073/pnas.1502609112. Epub 2015 Apr 20.PMID:25902531 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
