Key features and details | |
Cat. No. | MABL-723 |
Name | Anti-CD147 mAbs |
Clone No. | AFD- OX-114 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, FC, IHC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | OX-114 binds to both the 2- and 3-domain isoforms of CD147. CD147 targets monocarboxylate transporters to the plasma membrane, and is involved in spermatogenesis, embryo implantation, neural network fomration and tumor progression. Stimulates production of matrix metalloproteases. Possibly a receptor for oligomannosidic glycans. CD147 found only in vascular endothelium in non-neoplastic regions of the brain whereas it is present in tmour cells but not in proliferating blood vessels in malignant gliomas. |
Alternative Name | Basigin; basic immunoglobulin superfamily; HT7 antigen; membrane glycoprotein gp42; gp42; gp-42; OX114; MRC OX-114; MRC OX114 |
UniProt | P18572 |
Immunogen | OX-114 was generated by immunizing rats with recombinant mCD147d0-2rCD4d3+4. |
Application Notes | This antibody binds mouse CD147, and has been used in FC and IHC-fr analysis to characterise CD147 and detect the cell types on which it is expressed, indicating that CD147 is a lymphocyte activation marker (Paterson, 1987). This antibody failed to give immunoprecipitates from radiolabelled activated T cells. |
Antibody First Published | Hanna et al. A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically. BMC Biochem 4:17 2003 PMID:14606962 |
Note on publication | Describes the original use of this antibody as part of FC and IP studies to identify new markers for activated T cells. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
