Key features and details | |
Cat. No. | MABL-744 |
Name | Anti-CD169 mAbs |
Clone No. | AFD- SER-4 (recombinant version) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IHC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody specifically recognize mouse CD169, which is a 180-185-kDa member of the Siglec family of macrophage-specific cell adhesion and endocytic receptors interacting with sialylated glycans. This receptor is expressed on a subset of macrophages that are found with high frequency in the spleen, liver, lymph node, and bone marrow. CD169 can also be detected on monocytes in the bone marrow and periphery. |
Alternative Name | Sialoadhesin; Sheep erythrocyte receptor; SER; Sialic acid-binding Ig-like lectin 1; Siglec-1 |
UniProt | Q62230 |
Immunogen | Spleen cells from AO rats immunised with thioglycollate-elicted murine peritoneal macrophages (TPM) that had been cutured in mouse serum to induce sheep erythrocyte receptor (SER). |
Application Notes | |
Antibody First Published | Crocker PR, Gordon S. Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. J Exp Med. 1989 Apr 1;169(4)：1333-46. PMID：2926328 |
Note on publication | Describes the making of SER-4 monoclonal antibody and characterizes the molecular nature and distribution on macrophage of SER with mAb SER-4 - inc data on IHC-Fr, IP and WB assays. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
