Key features and details | |
Cat. No. | MABL-808 |
Name | Anti-CD22 mAbs |
Clone No. | AFD- LL2 (EPB2) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognises CD22, which is a cytoplasmic molecule expressed in progenitor and early-pre B cells. |
Alternative Name | Leu14; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL- CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; EPB2; EPB-2 |
UniProt | P20273 |
Immunogen | This antibody was raised by immunising Balb/c mice with Raji cells or a fragmented cell mixture. |
Application Notes | This antibody has been used in research on the diagnosis and treatment of non- Hodgkin's B cell lymphoma. Specificity to B-cell line of the LL2 (EPB-2) antibody was confirmed by radioimmunobinding and flow cytometry, where it did not bind to any other targets, such as T cells and normal diploid cells at the same time labelling malignant lymphoma tissue (Pawlak-Byczkowska et al., 1989). |
Antibody First Published | Pawlak-Byczkowska et al. Two new monoclonal antibodies, EPB-1 and EPB- 2, reactive with human lymphoma. Cancer Res. 1989 Aug 15;49(16)：4568-77. PMID：2663143 |
Note on publication | This article describes the generation and characterisation of the LL2 (EPB-2) antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
