Key features and details | |
Cat. No. | MABL-809 |
Name | Anti-CD22 mAbs |
Clone No. | AFD- MB22-11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, inhibition, ELISA |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody is specific for mouse CD22. |
Alternative Name | CD22; BL-CAM; B-cell receptor CD22; Siglec-2; T-cell surface antigen Leu- 14; Sialic acid-binding Ig-like lectin 2; B-lymphocyte cell adhesion molecule |
UniProt | P35329 |
Immunogen | The original antibody was raised by immunizing a CD22-/- mice with mouse CD22. |
Application Notes | The ability of the original antibody to deplete B cell in vivo in mice was tested. It showed that is was able to deplete B cells NZB/W F1 and C57BL/6 mice. This antibody was used for an ELISA (Haas et al., 2010; PMID |
Antibody First Published | Haas et al. CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo J Immunol. 2006 Sep 1;177(5)：3063-73. PMID：16920943 |
Note on publication | In the original paper mouse anti-mouse CD22 mAbs were generated that inhibit CD22 ligand binding to varying degrees, to understand how CD22 ligand interactions affect B cell function in vivo. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
