Anti-CD257 (BAFF) mAbs

Cat. No.

MABL-836

Name

Anti-CD257 (BAFF) mAbs

Clone No.

AFD- ABL-1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human BAFF protein.   B-cell-activating factor (BAFF/CD257) is a cytokine belonging to the   tumour-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI,   TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF is a survival factor for B cells   that controls B-cell maturation. It is also involved in the stimulation of B-   and T-cell function and the regulation of humoral immunity.

Alternative Name

BLyS;   TNFSF13B; TALL-1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily   member 13B; B lymphocyte stimulator; B-cell-activating factor; Dendritic   cell-derived TNF-like molecule; TNF and APOL-related leukocyte expressed ligand 1

UniProt

Q9Y275

Immunogen

The original antibody was generated by   immunizing mice with human BAFF protein.

Application Notes

This antibody binds recombinant human BAFF (amino   acids A134-L285) with a binding affinity of 0.9 X 10^(-8) M. This antibody   does not cross react with APRIL protein. This antibody was also capable of   detecting native and recombinant forms of human BAFF protein in a western   blot assay (PMID： 16023370).

Antibody First Published

Cao et al. Production and characterization   of a bacterial single-chain antibody fragment specific to B-cell-activating   factor of the TNF family. Protein Expr Purif. 2005 Oct;43(2)：157-64. PMID：16023370

Note on publication

Describes the generation and   characterization of a single chain antibody against human BAFF.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.