Key features and details | |
Cat. No. | MABL-840 |
Name | Anti-CD257 (BAFF) mAbs |
Clone No. | AFD- NMB04 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, inhibit, Block |
Species Reactivity | Human, Cynomolgus Monkey, Mouse |
Basic Information | |
Specificity | his antibody binds human BAFF protein and cross reacts with mouse and cynomolgus monkey BAFF protein. B-cell-activating factor (BAFF/CD257) is a cytokine belonging to the tumour-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF is a survival factor for B cells that controls B-cell maturation. It is also involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
Alternative Name | BLyS; TNFSF13B; TALL-1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; B-cell-activating factor; Dendritic cell-derived TNF-like molecule; TNF and APOL-related leukocyte expressed ligand 1 |
UniProt | Q9Y275 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with purified His tagged human BAFF protein. |
Application Notes | This antibody is capable of inhibiting the Blys signaling pathway by binding to Blys to block its binding to the receptor. The blocking activity of this antibody was reported to be better than Belimumab. In vitro, this antibody inhibited Blys-stimulated B cell proliferation and also inhibited Blys- stimulated mouse splenocyte proliferation. The original IgG1 version of this antibody binds BLyS with a very high binding affinity of Kd= 7.38E-10M. This antibody significantly inhibited human BLYS-induced activation and proliferation of splenic B cells in vivo (CN105061596). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
