Key features and details | |
Cat. No. | MABL-858 |
Name | Anti-CD28 mAbs |
Clone No. | AFD- E18 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | immunosuppression, SPR, Block, FC, IHC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | Recognises mouse CD28 at the interaction site with B7 and blocks binding to B7. Intact antibody (but not Fab fragments) trigger Treg proliferation in pro-inflammatory settings, and protect from graft-versus-host disease. |
Alternative Name | TP44; T-cell-specific surface glycoprotein CD28; TP44 |
UniProt | P31041 |
Immunogen | |
Application Notes | Further functional characterisation of the antibody may be found here . This antibody does not comete with D665 (Ab00285). |
Antibody First Published | Dennehy et al. Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses Journal of Immunology PMID:16670276 |
Note on publication | Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
